| Scott Lowell | .... | Theodore 'Ted' Schmidt (83 episodes) (2000-2005) |
| Hal Sparks | .... | Michael Charles Novotny-Bruckner / ... (83 episodes) (2000-2005) |
| Gale Harold | .... | Brian Kinney (82 episodes) (2000-2005) |
| Randy Harrison | .... | Justin Taylor (82 episodes) (2000-2005) |
| Peter Paige | .... | Emmett Honeycutt (82 episodes) (2000-2005) |
| Michelle Clunie | .... | Melanie 'Mel' Marcus (81 episodes) (2000-2005) |
| Thea Gill | .... | Lindsay 'Linz' Peterson (80 episodes) (2000-2005) |
| Sharon Gless | .... | Deborah 'Debbie' Jane Grassi Novotny (79 episodes) (2000-2005) |
| Robert Gant | .... | Professor Ben Bruckner-Novotny / ... (56 episodes) (2002-2005) |
| Jack Wetherall | .... | Vic Grassi (46 episodes) (2000-2004) |
| Makyla Smith | .... | Daphne Chanders (36 episodes) (2000-2005) |
| Gale Harold | .... | Brian Kinney (83 episodes) (2000-2005) |
| Randy Harrison | .... | Justin Taylor (83 episodes) (2000-2005) |
| Scott Lowell | .... | Theodore 'Ted' Schmidt (83 episodes) (2000-2005) |
| Peter Paige | .... | Emmett Honeycutt (83 episodes) (2000-2005) |
| Hal Sparks | .... | Michael Charles Novotny-Bruckner / ... (83 episodes) (2000-2005) |
| Michelle Clunie | .... | Melanie 'Mel' Marcus (82 episodes) (2000-2005) |
| Thea Gill | .... | Lindsay 'Linz' Peterson (81 episodes) (2000-2005) |
| Sharon Gless | .... | Deborah 'Debbie' Jane Grassi Novotny (80 episodes) (2000-2005) |
| Robert Gant | .... | Professor Ben Bruckner-Novotny / ... (56 episodes) (2002-2005) |
| Jack Wetherall | .... | Vic Grassi (46 episodes) (2000-2004) |
| Makyla Smith | .... | Daphne Chanders (35 episodes) (2000-2005) |